Journal article
Wesley Chiang, Angela Stout, Francine Yanchik-Slade, Herman Li, N. Terrando, Bradley L. Nilsson, H. Gelbard, Todd D. Krauss
ACS Applied Nano Materials, 2023
ACS Applied Nano Materials, 2023
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APA
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Chiang, W., Stout, A., Yanchik-Slade, F., Li, H., Terrando, N., Nilsson, B. L., … Krauss, T. D. (2023). Quantum Dot Biomimetic for SARS-CoV-2 to Interrogate Blood–Brain Barrier Damage Relevant to NeuroCOVID Brain Inflammation. ACS Applied Nano Materials.
Chicago/Turabian
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Chiang, Wesley, Angela Stout, Francine Yanchik-Slade, Herman Li, N. Terrando, Bradley L. Nilsson, H. Gelbard, and Todd D. Krauss. “Quantum Dot Biomimetic for SARS-CoV-2 to Interrogate Blood–Brain Barrier Damage Relevant to NeuroCOVID Brain Inflammation.” ACS Applied Nano Materials (2023).
MLA
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Chiang, Wesley, et al. “Quantum Dot Biomimetic for SARS-CoV-2 to Interrogate Blood–Brain Barrier Damage Relevant to NeuroCOVID Brain Inflammation.” ACS Applied Nano Materials, 2023.
BibTeX Click to copy
@article{wesley2023a,
title = {Quantum Dot Biomimetic for SARS-CoV-2 to Interrogate Blood–Brain Barrier Damage Relevant to NeuroCOVID Brain Inflammation},
year = {2023},
journal = {ACS Applied Nano Materials},
author = {Chiang, Wesley and Stout, Angela and Yanchik-Slade, Francine and Li, Herman and Terrando, N. and Nilsson, Bradley L. and Gelbard, H. and Krauss, Todd D.}
}
Abstract
Despite limited evidence for infection of SARS-CoV-2 in the central nervous system, cognitive impairment is a common complication reported in “recovered” COVID-19 patients. Identification of the origins of these neurological impairments is essential to inform therapeutic designs against them. However, such studies are limited, in part, by the current status of high-fidelity probes to visually investigate the effects of SARS-CoV-2 on the system of blood vessels and nerve cells in the brain, called the neurovascular unit. Here, we report that nanocrystal quantum dot micelles decorated with spike protein (COVID-QDs) are able to interrogate neurological damage due to SARS-CoV-2. In a transwell co-culture model of the neurovascular unit, exposure of brain endothelial cells to COVID-QDs elicited an inflammatory response in neurons and astrocytes without direct interaction with the COVID-QDs. These results provide compelling evidence of an inflammatory response without direct exposure to SARS-CoV-2-like nanoparticles. Additionally, we found that pretreatment with a neuro-protective molecule prevented endothelial cell damage resulting in substantial neurological protection. These results will accelerate studies into the mechanisms by which SARS-CoV-2 mediates neurologic dysfunction.